Electrochemotherapy is a local treatment of cancer employing electric pulses to\nimprove transmembrane transfer of cytotoxic drugs. In this paper we discuss\nelectrochemotherapy from the perspective of biomedical engineering and review\nthe steps needed to move such a treatment from initial prototypes into clinical\npractice. In the paper also basic theory of electrochemotherapy and preclinical studies\nin vitro and in vivo are briefly reviewed. Following this we present a short review of\nrecent clinical publications and discuss implementation of electrochemotherapy into\nstandard of care for treatment of skin tumors, and use of electrochemotherapy for\nother targets such as head and neck cancer, deep-seated tumors in the liver and\nintestinal tract, and brain metastases. Electrodes used in these specific cases are\npresented with their typical voltage amplitudes used in electrochemotherapy. Finally,\nkey points on what should be investigated in the future are presented and discussed.
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